49 W. 27th St. (btw Broadway & 6th Ave.)
Hands down my favorite speakeasy. Patent Pending opened in June 2018 and has some of the most interesting cocktails I've ever seen (and they change seasonally). You enter through a coffee shop door and there will be a woman standing there taking names of walk-ins (if they don't have space, they'll text you when a spot opens up). I'd go for a date night or post-dinner drink and probably only one person if it's a weekend night. I had the Summer of 1896 which had mezcal, Jamaican rum, yuzukosho, pineapple, cilantro, and lime. Hell freaking yes.